Analysis Note

ControlEmbryonic rat brain (day 16) tissue lysate.

Application

Research CategoryNeuroscience

Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC.

Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University.

Research Sub CategorySynapse & Synaptic Biology

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast

Immunogen

Epitope: Internal Domain

KLH conjugated synthetic linear peptide.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Purified rabbit polyclonal antibody in PBS with 0.05% NaN3.

Antigen Affinity Purified

Quality

Western Blot:
A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.

Specificity

Cat. # AB10140 detects the internal domain of Drebrin A/E.

May react with human based on sequence homology. Reactivity with other species has not been determined.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~77 kDa